The OVERTURE trial tested a wearable headset delivering 40Hz light and sound stimulation in patients with mild‑to‑moderate Alzheimer's. Results showed 84% slower functional decline (activities of daily living) and 74% slower progression on the MMSE cognitive test compared to controls. No effect on amyloid β aggregates was observed. The intervention was extremely safe and well‑tolerated.
A 34‑country study (n=18,701) found that physical exposome (pollution, climate) accelerated structural brain aging, while social exposome (inequality, social support) was more strongly linked to functional brain aging. Exposome burden accounted for up to 9× higher risk of accelerated brain aging — exceeding the effect of clinical diagnoses.
In a mouse model of temporal lobe epilepsy, the targeted senolytic SSK1 reduced p16+ senescent cells by ~45% in the hippocampus and thalamus, 60% of treated animals became seizure‑free, and spatial memory normalised. This suggests that senolytics may have cognitive benefits beyond aging.